Invitrogen™ Human Growth Hormone Recombinant Protein

Description

Recombinant Protein

This is a recombinant protein suitable for use as a control in ELISA and Western blot applications. Store lyophilized product desiccated at -20° C. Upon reconstitution, store at 4° C for 2-7 days or aliquot and store at -20° C. For long term storage add either HSA or BSA to 0.1%. Avoid repeated freeze/thaw cycles. Reconstitute using distilled water to a concentration not less than 100 μg/mL.

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.

Specifications

• Accession Number: P01241
• Concentration: 100 μg/mL
• For Use With (Application): Control
• Formulation: protein with no preservative
• Gene ID (Entrez): 2688
• Molecular Weight (g/mol): 22.260 kDa
• Name: Human Growth Hormone
• Quantity: 500 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1 ng/μg
• Gene Alias: dog growth hormone; GH; Gh1; GHB1; GHB5; GHN; GH-N; Growth hormone; growth hormone 1; growth hormone 12; growth hormone B1; growth hormone B5; growth hormone precursor; HGH; hGH-N; IGHD1B; pituitary growth hormone; RNGHGP; Somatotropin
• Common Name: Growth Hormone
• Gene Symbol: GH1
• Biological Activity: Fully biologically active as compared to WHO reference standard at 3 U/mg
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Human Growth Hormone recombinant protein contains 192 amino acids
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Lyophilized
• Protein Subtype: Recombinant

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov