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Invitrogen™ GSDMD Polyclonal Antibody
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Catalog No. PIPA5115330
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100 μL
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PIPA5115330 100 μL
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Catalog No. PIPA5115330 Supplier Invitrogen™ Supplier No. PA5115330
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GSDMD protein, including precursor and the cleaved N-terminal fragment.

GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GSDMD
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene GSDMD
Gene Accession No. P57764, Q9D8T2
Gene Alias 1810036L03Rik; AW558049; DF5L; Dfna5l; FKSG10; gasdermin D; gasdermin domain containing 1; gasdermin domain-containing protein 1; Gasdermin-D; Gasdermin-D, C-terminal; Gasdermin-D, N-terminal; GSDMD; GSDMDC1; GSDMD-CT; GSDMD-NT; M2-4
Gene Symbols GSDMD
Host Species Rabbit
Immunogen A synthesized peptide derived from human GSDMD(Accession P57764), corresponding to amino acid residues W50-G100.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 315084, 69146, 79792
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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