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Invitrogen™ GSDMD Recombinant Rabbit Monoclonal Antibody (PD00-18)
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Catalog No. FEMA550686
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FEMA550686 100 μL
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Catalog No. FEMA550686 Supplier Invitrogen™ Supplier No. MA550686
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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: PC-3 cell lysate, NIH/3T3 cell lysate, THP-1 cell lysate, THP-1 cell lysate treated with PMA for 17.5 hours and then treated with LPS for 6 hours, PC-12 cell lysate, PMVEC cell lysate, RH-35 cell lysate, L6 cell lysate. Predicted band size: 53/30 kDa Subcellular Location: Cell membrane, Secreted.

GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GSDMD
Applications Western Blot
Classification Recombinant Monoclonal
Clone PD00-18
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene GSDMD
Gene Accession No. P57764, Q9D8T2
Gene Alias 1810036L03Rik; AW558049; DF5L; Dfna5l; FKSG10; gasdermin D; gasdermin domain containing 1; gasdermin domain-containing protein 1; Gasdermin-D; Gasdermin-D, C-terminal; Gasdermin-D, N-terminal; GSDMD; GSDMDC1; GSDMD-CT; GSDMD-NT; M2-4
Gene Symbols GSDMD
Host Species Rabbit
Immunogen Recombinant protein within GSDMD full length protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 315084, 69146, 79792
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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