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Apexbio Technology LLC GSK621 1346607-05-3 10mg
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Supplier:  Apexbio Technology LLC B602010

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GSK621 (CAS 1346607-05-3) is a selective activator of AMP-activated protein kinase (AMPK) a serine/threonine kinase that functions as a cellular energy sensor regulating diverse metabolic pathways In cell-based assays GSK621 activates AMPK with IC50 values between 13 and 30 M Activation of AMPK by GSK621 leads to phosphorylation and inactivation of acetyl-CoA carboxylase (ACC) suppression of fatty acid synthesis inhibition of mTORC1-mediated protein synthesis and promotion of processes such as autophagy fatty acid oxidation and glucose uptake In acute myeloid leukemia (AML) cell lines and xenograft models GSK621 enhances phosphorylation of AMPK substrates and demonstrates antileukemic effects supporting its utility in studies of cellular metabolism and cancer biology

Catalog No. 50-000-90286


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