Invitrogen™ GTF2B Monoclonal Antibody (3H2)

Catalog No.	Quantity
PIMA524864	100 μL

Catalog No. PIMA524864 Supplier Invitrogen™ Supplier No. MA524864

Description

Mouse Monoclonal Antibody

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.

Specifications

• Antigen: GTF2B
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 3H2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: GTF2B
• Gene Accession No.: Q00403
• Gene Alias: general transcription factor 2B L homeolog; general transcription factor IIB; general transcription factor TFIIB; GTF2B; gtf2b.L; gtf2b-a; gtf2b-b; LOW QUALITY PROTEIN: transcription initiation factor IIB; MGC137096 protein; RNA polymerase II alpha initiation factor; RNA polymerase II transcription factor IIB; RP11-82K18.1; S300-II; TF2B; tfiib; Transcription initiation factor IIB; Transcription initiation factor IIB-like protein; wu:fc44c11; XELAEV_18023356mg; XLTFIIB; zgc:66258
• Gene Symbols: GTF2B
• Host Species: Mouse
• Immunogen: Recombinant full length Human GTF2B.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2959
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b