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Description
- Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity.
- A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase.
- In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.
- Guanidine Thiocyanate is a chaotropic agent and strong protein denaturant which inactivates nucleases approximately 2.5 times faster than guanidine hydrochloride.
Specifications
Specifications
| Melting Point | 115°C to 122°C |
| Color | White |
| pH | 5 to 7 (6M aq soln) |
| Loss on Drying | <1% |
| Quantity | 500 g |
| UN Number | UN1759 |
| Beilstein | 3563461 |
| Solubility Information | Soluble in (6.0 M aq soln): Clear, Colorless Solution. |
| Grade | >98% |
| Physical Form | Crystalline Granules |
Safety and Handling
| storageNote1 | Store at Room Temperature (15-30°C). Protect from light. |
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