Guanosine-5'-Triphosphate Disodium Salt, MP Biomedicals™

Description

Required as a coenzyme for protein biosynthesis in a cell-free system. Guanosine-5'-Triphosphate Disodium Salt, MP Biomedicals (GTP) is a purine nucleotide that functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy

GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

GTP is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exchange factors (GEF).

Specifications

Chemical Identifiers

• CAS: 56001-37-7
• Molecular Formula: C10H14N5Na2O14P3
• Molecular Weight (g/mol): 567.14
• MDL Number: MFCD03410297
• InChI Key: FIZIYLKEXVIRHJ-KHRSEZDTNA-L
• Synonym: guanosine 5'-triphosphate, guanosine-5'-triphosphate disodium salt dihydrate gtp, guanosine-triphosphate, guanosine 5'-triphosphate 4-, gtp 4-, 2r,3s,4r,5r-5-2-amino-6-hydroxy-9h-purin-9-yl-3,4-dihydroxyoxolan-2-yl methyl phosphonato oxy phosphonatooxy phosphinate, 2r,3s,4r,5r-5-2-amino-6-oxo-3h-purin-9-yl-3,4-dihydroxyoxolan-2-yl methoxy-oxidophosphoryl oxy-oxidophosphoryl phosphate
• PubChem CID: 131676145
• IUPAC Name: disodium;(2R,3R,4S,5R)-2-(2-amino-6-oxo-3H-purin-9-yl)-5-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolane-3,4-diolate
• SMILES: [Na+].[Na+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1

• Physical Form: Powder
• Quantity: 100 mg
• Solubility Information: Soluble in water (50mg/mL - clear and colorless).
• Formula Weight: 567.2
• Percent Purity: ≥98%

Safety and Handling

Recommended Storage

−20°C.