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Thermo Scientific Chemicals GW-405833

Catalog No. AAJ67425MA
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Description

CAS: 180002-83-9 | C23H24Cl2N2O3, C23H24Cl2N2O3 | 447.36 g/mol

It is a potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ∼ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 180002-83-9
Molecular Formula C23H24Cl2N2O3
Molecular Weight (g/mol) 447.36
InChI Key FSFZRNZSZYDVLI-UHFFFAOYSA-N
Synonym L-768242; 1-(2,3-Dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]indole
IUPAC Name 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-3-[2-(morpholin-4-yl)ethyl]-1H-indole
SMILES COC1=CC=C2N(C(=O)C3=C(Cl)C(Cl)=CC=C3)C(C)=C(CCN3CCOCC3)C2=C1

Specifications

Quantity 10 mg
Description Off-white
Content And Storage -30°C to -10°C
Formula Weight 447.36
Melting Point 47°C to 49°C
Solubility Soluble in DMSO at 10-15mg/ml. Also soluble in ethanol at ∽5mg/ml.
Product Type GW-405833
Form Solid

Safety and Handling

Recommended Storage Store at -20°C
SDS

RUO – Research Use Only

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