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Cayman Chemical GW 4869 (hydrochloride hydrate), 6823-69-4, 1 mg

Supplier: Cayman Chemical 131271

Molecular Formula C30H28N6O2 • 2HCl [XH2O], Purity ≥90%, Formula Weight 577.5; An inhibitor of neutral sphingomyelinase (IC50 = 1 M); selective for neutral sphingomyelinase over acid sphingomyelinase at concentrations up to 150 M as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 M; inhibits TNF--induced sphingomyelin hydrolysis and TNF--induced cell death in MCF-7 cells; reduces the inhibitory effects of OxPAPC and KOdiA-PE on LPS-induction of IL-8 in human aortic endothelial cells; reverses hypoxia-induced pulmonary vasoconstriction in rats at 1 mg/kg.
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