Invitrogen™ H1FOO Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536111

Catalog No. PIPA536111

Description

This antibody detects endogenous protein at a molecular weight of 35 kDa. Purity is >95% by SDS-PAGE.

Eukaryotic Histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fibers. Two molecules of each of the four core Histones (Histone H2A, H2B, H3, and H4) form the octamer, which consists of two H2A-H2B dimers and two H3-H4 dimers that are nearly symmetrical by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene, that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. H1FOO (H1 histone family, member O, oocyte-specific), also known as OSH1, is a 346 amino acid oocyte-specific Histone that localizes to both the nucleus and the cytoplasm. Expressed as multiple alternatively spliced isoforms, H1FOO is thought to play an important role in gene control during oogenesis and early embryogenesis and is crucial for meiotic maturation of germinal vesicle-stage oocytes.

Specifications

• Antigen: H1FOO
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H1FOO
• Gene Alias: C86609; H1 histone family member O, oocyte specific; H1 histone family, member O, oocyte-specific; H1.8; H1fo; H1foo; H1OO; Histone H1oo; oocyte-specific histone H1; Oocyte-specific linker histone H1; OSH1; RGD1566236
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 132243
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: Q8IZA3
• Gene Symbols: H1FOO
• Immunogen: Synthetic peptide corresponding to the N-terminal of human Histone H1oo.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov