HACE1 Monoclonal Antibody (OTI2C7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA810064

Catalog No. 50-168-3175

Description

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Specifications

• Antigen: HACE1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8IYU2
• Gene Symbols: HACE1
• Immunogen: Full length human recombit protein of human HACE1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2C7
• Conjugate: Unconjugated
• Gene: HACE1
• Gene Alias: SPPRS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57531
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid