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Invitrogen™ HAS1 Monoclonal Antibody (3E10)
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Catalog No. PIMA515671
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PIMA515671 100 μL
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Catalog No. PIMA515671 Supplier Invitrogen™ Supplier No. MA515671
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Description

Mouse Monoclonal Antibody

MA5-15671 targets HAS1 in indirect ELISA, IF and WB applications and shows reactivity with Human samples. The MA5-15671 immunogen is purified recombinant fragment of human HAS1 expressed in E. Coli. MA5-15671 detects HAS1 which has a predicted molecular weight of approximately 65kDa.

Hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAS1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3E10
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene Has1
Gene Accession No. Q92839
Gene Alias HA synthase 1; HAS; Has1; huHAS1; Hyaluronan synthase 1; hyaluronan synthase1; hyaluronate synthase 1; Hyaluronic acid synthase 1
Gene Symbols Has1
Host Species Mouse
Immunogen Purified recombinant fragment of human HAS1 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3036
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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