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Invitrogen™ hCG beta Monoclonal Antibody (28A4), HRP

Catalog No. PIMA121651
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200 μg
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Catalog No. Quantity
PIMA121651 200 μg
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Catalog No. PIMA121651 Supplier Invitrogen™ Supplier No. MA121651

Description

Mouse Monoclonal Antibody

This antibody specifically recognizes the beta-subunit of HCG, and does not cross-react with hLH, hTSH, hFSH.

hCG beta is the beta chain of hCG (Human chorionic gonadotropin), a 40 kDa glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. hCG is made up of alpha and beta subunits that are non-covalently associated. The alpha subunit is similar to those found on the pituitary hormones FSH, LH ans TSH. However, the beta subunit is different in FSH, LH and TSH and are involved in conferring biological specificity. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and Beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). Diseases associated with Hcg dysfunction include gestational trophoblastic tumor and hydatidiform mole, recurrent 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen hCG beta
Applications ELISA
Classification Monoclonal
Clone 28A4
Concentration 1.1 mg/mL
Conjugate HRP
Formulation PBS with 0.05% ProClin 300; pH 7.4
Gene CGB3
Gene Accession No. P0DN86
Gene Alias CGB; CGB3; CGB5; CGB7; CGB8; CG-beta; Choriogonadotropin subunit beta; choriogonadotropin subunit beta 3; chorionic gonadotrophin chain beta; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin beta subunit; chorionic gonadotropin beta subunit 3; chorionic gonadotropin chain beta; chorionic gonadotropin human; chorionic gonadotropin, beta polypeptide; FSH-alpha; hCGB; human chorionic gonadotropin; LSH-alpha; TSH-alpha
Gene Symbols CGB3
Host Species Mouse
Immunogen Recombinant full length protein (Human).
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1082
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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