Invitrogen™ HCK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589892

Catalog No. PIPA589892

Description

Immunogen sequence: LKSDEGSKQP LPKLIDFSAQ IAEGMAFIEQ RNYIHRDLRA ANILVSASLV CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGSF TIKSDVWSFG ILLMEIVTYG RIPYPGMSNP EVIRALERGY RMPRPENCPE ELYNIMMRCW KNRPEERPTF EYIQSVLDDF YTATESQYQQ QP; Positive Samples: Raji, Mouse spleen, Mouse lung, Rat spleen; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Lipid-anchor, Lysosome, Membrane, Nucleus, caveola, cytoskeleton, cytosol, cytosol, focal adhesion, podosome membrane, secretory vesicle.

Hematopoietic cell kinase (HCK) is a SRC-related kinase expressed in lymphoid and hematopoietic cells and may play a role in some forms of leukemia. (HCK Alias: DKFZp686D0638). HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

Specifications

• Antigen: HCK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HCK
• Gene Alias: AI849071; B cell/myeloid kinase; B-cell/myeloid kinase; BMK; HCK; HCK proto-oncogene, Src family tyrosine kinase; Hctk; Hematopoietic cell kinase; hemopoietic cell kinase; hemopoietic cell tyrosine kinase; JTK9; p56Hck; p56-HCK; p56-HCK/p59-HCK; p59Hck; p59-HCK/p60-HCK; p61Hck; tyrosine-protein kinase HCK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15162, 25734, 3055
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.55 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P08103, P08631, P50545
• Gene Symbols: HCK
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 324-505 of human HCK (NP_0011656001).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG