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Invitrogen™ HCN1 Monoclonal Antibody (RTQ 7C3), eBioscience™
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Catalog No. 14569182
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14-569-182 100 μg
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Catalog No. 14-569-182 Supplier Invitrogen™ Supplier No. 14569182
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Description

Rat Monoclonal Antibody

Description: This RTQ 7C3 monoclonal antibody recognizes mouse and rat HCN1. Clone RTQ 7C3 detects a ~110 kDa band corresponding to HCN1 by Western Blot. Applications Reported: This RTQ 7C3 antibody has been reported for use in western blot. Applications Tested: This RTQ 7C3 antibody has been tested by western blot of mouse and rat tissue lysates. This may be used at less than or equal to 1 μg/mL.

HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
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Specifications

Antigen HCN1
Applications Western Blot
Classification Monoclonal
Clone RTQ 7C3
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene HCN1
Gene Accession No. O88704, Q9JKB0
Gene Alias Bcng1; BCNG-1; Brain cyclic nucleotide-gated channel 1; C630013B14Rik; EIEE24; Hac2; HAC-2; Hcn1; hyperpolarization activated cyclic nucleotide gated potassium channel 1; hyperpolarization-activated cation channel 2; hyperpolarization-activated cyclic nucleotide-gated potassium channel 1; hyperpolarization-activated, cyclic nucleotide-gated K+ 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Symbols HCN1
Host Species Rat
Immunogen aa 650 - 685 of rat HCN1.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15165, 84390
Target Species Mouse, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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