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Apexbio Technology LLC HDM201 1448867-41-1 5mg
Supplier: Apexbio Technology LLC B83205
HDM201 (CAS 1448867-41-1) also known as Siremadlin or NVP-HDM201 is a selective small molecule inhibitor targeting the interaction between the E3 ubiquitin ligase Mdm2 and the tumor suppressor protein p53 HDM201 binds with picomolar affinity to the p53-binding site on Mdm2 demonstrating over 10 000-fold selectivity compared to Mdm4 By disrupting the Mdm2-p53 protein-protein interaction HDM201 stabilizes and activates p53 thereby promoting p53-dependent cellular responses This compound serves as a valuable tool for investigating p53 pathway activation and for exploring therapeutic strategies aimed at reactivating p53 in cancer research models
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