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Invitrogen™ HEF1 Polyclonal Antibody
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Catalog No. PIPA579727
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100 μg
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PIPA579727 100 μg
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Catalog No. PIPA579727 Supplier Invitrogen™ Supplier No. PA579727
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human A549 whole cell, human Daudi whole cell, monkey COS-7 whole cell, human MCF-7 whole cell, rat spleen tissue, mouse spleen tissue. IHC: human breast cancer tissue. ICC/IF: Hela cell. Flow: A549 cell.

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HEF1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene NEDD9
Gene Accession No. O35177, Q14511
Gene Alias Cas scaffolding protein family member 2; CAS2; CASL; CAS-L; cas-like docking; CASS2; Crk-associated substrate lymphocyte-specific protein; Crk-associated substrate related protein Cas-L; CRK-associated substrate-related protein; dJ49G10.2; dJ761I2.1; Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF1; mEF1; Nedd9; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; neural precursor cell expressed, developmentally down-regulated gene 9; p105; p130Cas-related protein; renal carcinoma antigen NY-REN-12
Gene Symbols NEDD9
Host Species Rabbit
Immunogen E.coli-derived human HEF1 recombinant protein (Position: K273-E421).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18003, 291044, 4739
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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