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Invitrogen™ Hepatitis B Virus Core Antigen Monoclonal Antibody (10C6)

Catalog No. 01670343 Shop All Thermo Scientific Products
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01-670-343 100 μg
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Catalog No. 01-670-343 Supplier Invitrogen™ Supplier No. MA17609
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Description

Mouse Monoclonal Antibody

This antibody can be used for ELISA, Western blot, IHC, and Immunoprecipitation of in vitro-translated core and pre-core proteins. Strongly recognizes WHc (but not DHBc) in ELISA and immunoblot. Reacts with synthetic HBc peptides. Epitope: aa 138-145.

The hepatitis B virus is an important cause of acute and chronic liver disease. It is also the most common form of parenterally transmitted viral hepatitis. Hepatitis B virus is spherical in shape with a diameter of 42nm. It contains a 27 nm partially double stranded DNA core enclosed within a lipoprotein coat. The antigenic activity of the nucleocapsid core is designated as hepatitis B core antigen. The antigens in the outer surface are called as hepatitis B virus surface antigens. Core antigens are localized within the nuclei whereas the surface antigens are present in the cytoplasm of the infected cells. Antibodies to surface antigens appear in circulation at an early stage of infection whereas the antibodies to the core antigens are detected after several weeks. The virus is estimated to affect some 350 million people worldwide. Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries. Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus. In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas. There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Hepatitis B Virus Core Antigen
Applications ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 10C6
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.01% sodium azide; pH 7.2
Gene Alias ayw; HBc; HBcAg; HBV; HepB
Host Species Mouse
Immunogen Recombinant HBcAg core antigen (ayw).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C short term, -80°C long term
Product Type Antibody
Form Liquid
Isotype IgG2b
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