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Invitrogen™ HERC5 Recombinant Rabbit Monoclonal Antibody (8H23L10)

Catalog No. 703675
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Catalog No. Quantity
70-367-5 100 μg
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Catalog No. 70-367-5 Supplier Invitrogen™ Supplier No. 703675
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Cat, Sheep. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HERC5
Applications Western Blot
Classification Recombinant Monoclonal
Clone 8H23L10
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene HERC5
Gene Accession No. Q9UII4
Gene Alias CEB1; CEBP1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HERC5; probable E3 ubiquitin-protein ligase HERC5
Gene Symbols HERC5
Host Species Rabbit
Immunogen Protein corresponding to human HERC5 [aa1-aa141].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51191
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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