HES6 Monoclonal Antibody (OTI1D6), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-8510	100 μL

Catalog No. 50-167-8510 Supplier OriGene Supplier No. TA800716

Description

Mouse Monoclonal Antibody

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Specifications

• Antigen: HES6
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1D6
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: HES6
• Gene Accession No.: Q96HZ4
• Gene Alias: C-HAIRY1, HES-6, bHLHb41, bHLHc23
• Gene Symbols: HES6
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human HES6 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55502
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1