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Invitrogen™ HES6 Polyclonal Antibody
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Catalog No. PIPA540617
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PIPA540617 100 μL
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Catalog No. PIPA540617 Supplier Invitrogen™ Supplier No. PA540617
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Description

Rabbit Polyclonal Antibody

Peptide sequence: PPGPGDDLCS DLEEAPEAEL SQAPAEGPDL VPAALGSLTT AQIARSVWRP Sequence homology: Dog: 86%; Human: 100%; Mouse: 79%; Rat: 86%.

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HES6
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene HES6
Gene Accession No. Q96HZ4
Gene Alias AI326893; bHLHb41; bHLHc23; C-HAIRY1; class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; hes family bHLH transcription factor 6; hes6; HES-6; Transcription cofactor HES-6
Gene Symbols HES6
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human HES6 (aa 174-223).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55502
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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