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Invitrogen™ HFE2 Polyclonal Antibody
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Catalog No. PIPA547529
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100 μg
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PIPA547529 100 μg
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Catalog No. PIPA547529 Supplier Invitrogen™ Supplier No. PA547529
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) RGM-B is observed and less than 5% cross-reactivity with rhRGM-A is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HFE2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene HFE2
Gene Accession No. Q6ZVN8, Q7TQ32
Gene Alias 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC
Gene Symbols HFE2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human RGM-C isoform a Gln36-Asp400.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 148738, 69585
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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