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Tocris Bioscience™ HG-9-91-01

Catalog No. 898550
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89-855-0 50 mg
89-851-0 10 mg
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Catalog No. 89-855-0 Supplier Tocris Bioscience™ Supplier No. 8985/50
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Description

Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.

HG-9-91-01 (SIK1 inhibitor) is a potent pan-salt inducible kinases (pan-SIKs) inhibitor (IC50 values are 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3 respectively). HG-9-91-01 inhibits latrunculin B (Lat-B)-induced endocrine progenitors (EP) differentiation via nuclear YAP1 accumulation in vitro. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in vitro. HG-9-91-01 increases β-cell proliferation in vitro and in vivo (mouse, zebrafish).

Specifications

Chemical Name or Material 1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
CAS 1456858-58-4
Quantity 50 mg
Target Other Kinase Inhibitors
Molecular Formula C32H37N7O3
Purity 98%
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