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  6. Invitrogen™ HGAL Monoclonal Antibody (1H1-A7), eBioscience™, Invitrogen™ 

Invitrogen™ HGAL Monoclonal Antibody (1H1-A7), eBioscience™, Invitrogen™
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Catalog No. 14975882
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14-975-882 100 μg
14-975-880 25 μg
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Catalog No. 14-975-882 Supplier Invitrogen™ Supplier No. 14975882
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Description

Mouse Monoclonal Antibody

The MAb 1H1-A7 recognizes human germinal center-associated lymphoma (HGAL) protein. HGAL is expressed in germinal centers, spleen, thymus, and germinal center-derived lymphomas. HGAL is localized to the cytoplasm of cells within the dark zone of the germinal center and functions to enhance the activation of RhoA leading to negative regulation of lymphocyte motility. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL). The 1H1-A7 antibody recognizes the protein product of the M17 gene, the mouse homolog of the HGAL protein.

GCET2 is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Specifications

Antigen HGAL
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 1H1-A7
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene GCSAM
Gene Accession No. Q6RFH4, Q8N6F7
Gene Alias GAL; GCAT2; Gcet; GCET2; GCET2 germinal center expressed transcript 2; GCSAM; Germinal center associated lymphoma (hGAL); germinal center associated signaling and motility; germinal center associated, signaling and motility; germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2; germinal center-associated lymphoma protein; Germinal center-associated signaling and motility protein; germinal center-associated, signaling and motility; HGAL; human germinal center-associated lymphoma; M17; M17-L; MGC40441
Gene Symbols GCSAM
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14525, 257144
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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