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HGAL Monoclonal Antibody (1H1-A7), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen 14975882

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Catalog No. 14-975-882


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Description

Description

The MAb 1H1-A7 recognizes human germinal center-associated lymphoma (HGAL) protein. HGAL is expressed in germinal centers, spleen, thymus, and germinal center-derived lymphomas. HGAL is localized to the cytoplasm of cells within the dark zone of the germinal center and functions to enhance the activation of RhoA leading to negative regulation of lymphocyte motility. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL). The 1H1-A7 antibody recognizes the protein product of the M17 gene, the mouse homolog of the HGAL protein.

GCET2 is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HGAL
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q6RFH4, Q8N6F7
GCSAM
Affinity chromatography
RUO
14525, 257144
4° C
Liquid
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1H1-A7
Unconjugated
GCSAM
GAL; GCAT2; Gcet; GCET2; GCET2 germinal center expressed transcript 2; GCSAM; Germinal center associated lymphoma (hGAL); germinal center associated signaling and motility; germinal center associated, signaling and motility; germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2; germinal center-associated lymphoma protein; Germinal center-associated signaling and motility protein; germinal center-associated, signaling and motility; HGAL; human germinal center-associated lymphoma; M17; M17-L; MGC40441
Mouse
100 μg
Primary
Human, Mouse
Antibody
IgG2a κ
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