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Invitrogen™ HIN-1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5121912
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20 μL
100 μL
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PIPA5121912 20 μL
PIPA5121911 100 μL
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Catalog No. PIPA5121912 Supplier Invitrogen™ Supplier No. PA5121912
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Description

Rabbit Polyclonal Antibody

HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIN-1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene SCGB3A1
Gene Accession No. Q96QR1
Gene Alias cytokine high in normal-1; cytokine HIN-1; High in normal 1; HIN1; HIN-1; LU105; pneumo secretory protein 2; PNSP2; PnSP-2; SCGB3A1; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867; UNQ629/PRO1245; Uteroglobin-related protein 2
Gene Symbols SCGB3A1
Host Species Rabbit
Immunogen Phe21-Gly104 (Accession Q96QR1), with N-terminal His and GST Tag.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100515999, 92304
Target Species Human, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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