HIRA Monoclonal Antibody (WC15), Active Motif™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-2718	Active Motif 39556	10 μg
50-199-2717	Active Motif 39555	100 μg

Description

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specifications

• Antigen: HIRA
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Alias: AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; Tuple1
• Gene Symbols: HIRA
• Isotype: IgG
• Purification Method: Protein G
• Product Type: Antibody

• Clone: WC15
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human, Mouse
• Gene Accession No.: P54198, Q61666
• Gene ID (Entrez): 15260, 7290
• Immunogen: This HIRA antibody was raised against a GST-fusion protein containing residues 421-729 of human HIRA.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: HIRA