Invitrogen™ HIRA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597065

Catalog No. PIPA597065

Description

Immunogen sequence: AQIIEREGWK TNMDFVGHRK AVTVVKFNPK IFKKKQKNGS SAKPSCPYCC CAVGSKDRSL SVWLTCLKRP LVVIHELFDK SIMDISWTLN GLGILVCSMD GSVAFLDFSQ DELGDPLSEE EKSRIHQSTY GKSLAIMTEA QLSTAVIENP EMLKYQRRQQ QQQLDQKSAA TREMGSATSV AGVVNGESLE DIRKNLLKKQ VETRTADGRR RITPLCIAQL DTGDFSTAFF NSIPLSGSLA GTMLSSHSSP QLLPLDSSTP NSFGASKPCT EPVVAASARP AGDSVNKDSM NATSTPAALS P; Positive Samples: 293T, HepG2, HeLa; Cellular Location: Nucleus, PML body.

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specifications

• Antigen: HIRA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HIRA
• Gene Alias: AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; TUPLE1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7290
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P54198
• Gene Symbols: HIRA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human HIRA (NP_0033163).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov