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HIST1H2BA Mouse anti-Human, Clone: OTI1C9, liquid, TrueMAB™
SDP

Catalog No. 501682018
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50-168-2018 100 μL
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Catalog No. 50-168-2018 Supplier OriGene Supplier No. TA808271
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Description

Mouse Monoclonal Antibody

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Specifications

Antigen HIST1H2BA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1C9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene HIST1H2BA
Gene Accession No. Q96A08
Gene Alias H2BFU, STBP, TH2B, TSH2B, TSH2B.1, bA317E16.3, hTSH2B
Gene Symbols HIST1H2BA
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 2-127 of human HIST1H2BA produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 255626
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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