Histamine

Description

CAS: 51-45-6 | C5H9N3 | 111.15 g/mol

Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Solubility
Soluble in water, alcohol, and hot chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Hygroscopic. Handle and store under inert gas. Air sensitive.

Specifications

Chemical Identifiers

• CAS: 51-45-6
• Molecular Formula: C5H9N3
• Molecular Weight (g/mol): 111.15
• MDL Number: MFCD00005210,MFCD00128939
• InChI Key: NTYJJOPFIAHURM-UHFFFAOYSA-N
• Synonym: histamine, 1h-imidazole-4-ethanamine, 2-4-imidazolyl ethylamine, ergotidine, 2-1h-imidazol-5-yl ethanamine, ergamine, eramin, 5-imidazoleethylamine, theramine, free histamine
• PubChem CID: 774
• ChEBI: CHEBI:18295
• SMILES: NCCC1=CN=CN1

• Color: White
• Quantity: 1 g
• UN Number: UN2811
• Beilstein: 2012
• Merck Index: 14,4719
• Solubility Information: Soluble in water,alcohol,and hot chloroform.
• IUPAC Name: 2-(1H-imidazol-5-yl)ethanamine
• Formula Weight: 111.15
• Physical Form: Powder
• Chemical Name or Material: Histamine

Safety and Handling

Hazard Category	H301-H315-H317-H319-H334-H335
Hazard Statement	GHS H Statement H301-H334-H315-H319-H317-H335 Toxic if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P272-P280-P285-P301+P310-P302+P352-P304+P340-P305+P351+P338-P330-P333+P313-P342+P311-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	200-100-6
RTECSNumber	MS1050000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only