Histone H3K27me3 Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3925	Active Motif 39158	10 μL
50-199-3924	Active Motif 39156	100 μL

Description

H3K27me3 is the epigenetic mark where histone H3 is trimethylated at lysine residue 27. H3K27me3 is an epigenetic silencing mark and thus associated with downregulation of nearby genes and often found in heterochromatin regions. H3K27me3 is mainly found at inactive gene promoters and generally is found in opposition to the activating mark H3K4me3. H3K27me3 often occupies gene rich regions with close association to development regulators. EZH2, a component of the PRC2 complex, is the histone methyltransferase (or writer) responsible for trimethylating H3K27. UTX and JMJD3 both are histone demethylases (or erasers) for H3K27me3. The regulation of H3K27me3 is crucial for gene regulation and dysregulation of H3K27me3 has been implicated in numerous diseases including cancer. H3K27me3 antibodies are often used for western blot and ChIP applications to study changes in levels and occupancy of H3K27me3.

Specifications

• Antigen: Histone H3K27me3
• Applications: ChIP Assay, Dot Blot, Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P02301, P68431, P68433, P84228, P84243, Q6NXT2, Q71DI3
• Gene ID (Entrez): 126961, 260423, 3020, 3021, 319150, 319152, 333932, 360198, 440093, 625328, 8350, 8357, 8358, 8968, 97114
• Immunogen: This Histone H3 trimethyl Lys27 antibody was raised against a peptide including trimethyl-lysine 27 of histone H3.
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: Conc. Not Determined
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
• Gene Alias: CG31613; CG31613 gene product from transcript CG31613-RA; CG31613-PA; CG33803; CG33806; CG33809; CG33812; CG33815; CG33818; CG33821; CG33824; CG33827; CG33830; CG33833; CG33836; CG33839; CG33842; CG33845; CG33848; CG33851; CG33854; CG33857; CG33860; CG33863; CG33866; Dmel\CG31613; Dmel_CG31613; H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3B.1; H3 histone, family 3C; H3 K27; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; h3.2a; H3.3A; H3.3b; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3B; H3-53; H3-614; H3a; H3b; H3-B; H3c1; H3c10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3c8; H3f; H3-F; H3F1K; H3F2; H3F3; h3f3a; H3F3B; h3f3b.1; h3f3c; h3f3d; H3FA; H3FB; H3FC HIST1H3C; H3F
• Gene Symbols: H3-3A, H3-3B, H3-5, H3C1, H3C10, H3C14, H3C15, H3C2, H3C7
• Isotype: IgG
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: H3-3A