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HLA-ABC Monoclonal Antibody (W6/32), Invitrogen™

Catalog No. MA170111
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500 μg
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MA170111 500 μg
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Description

Mouse Monoclonal Antibody

MA1-70111 detects HLA-ABC in human samples. MA1-70111 has been successfully used in flow cytometry, functional assay, and immunoprecipitation procedures. The MA1-70111 immunogen is purified membrane of human tonsil cells. Store at 4°C short term. For extended storage aliquot and store at -20°C. Avoid Freeze/Thaw Cycles.

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HLA-ABC
Applications Flow Cytometry, Functional Assay, Immunoprecipitation
Classification Monoclonal
Clone W6/32
Concentration 1 mg/mL
Conjugate Unconjugated
Gene HLA-A
Gene Accession No. P10321, P01889, P05534
Gene Alias MHC Class 1, MHC class I, MHC I HLA, HLA-A, HLA-B, HLA-C, MHC HLA-ABC, HLA-B 1502
Gene Symbols HLA-A, HLA-B, HLA-C
Host Species Mouse
Immunogen Purified membrane of human tonsil cells.
Purification Method Protein G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3105, 3106, 3107
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a
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