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HLA Monoclonal Antibody (OTI4G7), TrueMAB™, OriGene
SDP

Catalog No. 501684435
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Catalog No. Quantity
50-168-4435 100 μL
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Catalog No. 50-168-4435 Supplier OriGene Supplier No. TA812174
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Description

Mouse Monoclonal Antibody

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Specifications

Antigen HLA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI4G7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene HLA-DRB5
Gene Accession No. Q30154
Gene Alias major histocompatibility complex, class II, DR beta 5
Gene Symbols HLA-DRB5
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 30-266 of human HLA-DRB5 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3127
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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