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Invitrogen™ HMGB1 Monoclonal Antibody (1F3)

Catalog No. p-7246475
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PIMA547291 500 μL
PIMA547388 100 μL
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Catalog No. PIMA547291 Supplier Invitrogen™ Supplier No. MA547291
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Description

Mouse Monoclonal Antibody

HMGB1 Monoclonal Antibody for Western Blot, IHC, ICC/IF

High-mobility group box 1 protein, previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. It is now known that HMGB1 can also act extracellularly, both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, and as a mediator of T cell-dendritic cell interaction. Moreover, HMGB1 is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HMGB1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1F3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 5mM sodium azide
Gene Hmgb1
Gene Accession No. P09429, P63158, P63159
Gene Alias Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Gene Symbols Hmgb1
Host Species Mouse
Immunogen Human full length recombinant human HMGB1 protein expressed in and purified from E. coli.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15289, 25459, 3146
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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