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Invitrogen™ HMGB1 Polyclonal Antibody
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Catalog No. 01950167
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01-950-167 100 μL
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Catalog No. 01-950-167 Supplier Invitrogen™ Supplier No. PA116926
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Description

Rabbit Polyclonal Antibody

This antibody is expected to cross react with porcine, equine and rabbit samples based on 100% sequence homology. Suggested positive control: Hela whole cell extract, antigen standard for HMGB1 (transient overexpression lysate).

High-mobility group box 1 protein, previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. It is now known that HMGB1 can also act extracellularly, both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, and as a mediator of T cell-dendritic cell interaction. Moreover, HMGB1 is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HMGB1
Applications ChIP Assay, ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Hmgb1
Gene Accession No. P09429, P10103, P63158, P63159, Q6YKA4
Gene Alias Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Gene Symbols Hmgb1, LOC101112071
Host Species Rabbit
Immunogen A synthetic peptide made to an internal portion of the human HMGB1 protein sequence (between residues 100-200).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100328641, 101112071, 15289, 25459, 282691, 3146, 403170
Target Species Human, Mouse, Rat, Canine, Rabbit, Bovine, Sheep
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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