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hnRNP-K Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300676AT

Encompass_Preferred

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Catalog No. 50-155-8189


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Specifications

Specifications

hnRNP-K
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
P61978, P61979
HNRNPK
Between 300 and 350
20 μL
Primary
Human, Mouse
Antibody
IgG
Immunohistochemistry, Western Blot
Unconjugated
HNRNPK
CSBP, TUNP, dC-stretch binding protein
Rabbit
Antigen affinity chromatography
RUO
15387, 3190
4° C
Liquid
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