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Invitrogen™ HnRNP Q Polyclonal Antibody
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Catalog No. PIPA515009
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400 μL
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PIPA515009 400 μL
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Catalog No. PIPA515009 Supplier Invitrogen™ Supplier No. PA515009
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse based on sequence homology.

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HnRNP Q
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Syncrip
Gene Accession No. O60506
Gene Alias 2610109K23Rik; 4632417O19Rik; Ab2-339; Glycine- and tyrosine-rich RNA-binding protein; GRYRBP; GRY-RBP; heterogeneous nuclear ribonucleoprotein Q; hnRNP; hnRNP Q; HNRNPQ; hnRNP-Q; HNRPQ; HNRPQ1; liver regeneration-related protein LRRG077; NS1-associated protein 1; NSAP1; Nsap1l; PP68; RRM RNA binding protein GRY-RBP; synaptotagmin binding cytoplasmic RNA interacting protein; synaptotagmin binding, cytoplasmic RNA interacting protein; synaptotagmin-binding, cytoplasmic RNA-interacting protein; Syncrip
Gene Symbols Syncrip
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 591-623 amino acids from the C-terminal region of human HNRPQ.
Purification Method Ammonium sulfate precipitation, Size-exclusion - Dialysis
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10492
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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