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Invitrogen™ HO-1 Monoclonal Antibody (1F12-A6), APC
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Catalog No. PIMA545152 Shop All Thermo Scientific Products
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100 μg
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PIMA545152 100 μg
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Catalog No. PIMA545152 Supplier Invitrogen™ Supplier No. MA545152
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Description

Mouse Monoclonal Antibody

1 μg/mL was sufficient for detection of HO-1 in 10 μg of mixed human cell line lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary. Detects 32kDa. Does not cross-react with HO-2.

Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HO-1
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1F12-A6
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.2
Gene HMOX1
Gene Accession No. P06762, P09601, P14901, P32394, Q5E9F2
Gene Alias bK286B10; D8Wsu38e; heat shock protein 32; heat shock protein, 32-kD; heme orygenase 1; heme oxygenase; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; heme oxygenase 1; heme oxygenase-1; Hemox; hemoxygenase; Heox; HEOXG; Hmox; Hmox1; HMOX1D; HO; Ho1; HO-1; Hsp32; P32 protein
Gene Symbols HMOX1
Host Species Mouse
Immunogen Human HO-1 synthetic peptide, amino acids 1-30.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100008919, 100715748, 100756872, 15368, 24451, 3162, 442987, 445512, 513221
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Guinea Pig
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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