Invitrogen™ HP1 alpha Monoclonal Antibody

Catalog No.	Quantity
PIMA1218	100 μg

Catalog No. PIMA1218 Supplier Invitrogen™ Supplier No. MA1218

Description

Mouse Monoclonal Antibody

MA1-218 detects CBX5 from human and non-human primate samples. CBX5 has an approximate molecular weight of 22.2kDa. MA1-218 has been successfully used in Western blot, immunofluorescence,and immunohistochemistry applications. The MA1-218 Immunogen is the purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E. Coli.

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Specifications

• Antigen: HP1 alpha
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Classification: Monoclonal
• Clone: Monoclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide; pH 7.2-7.4
• Gene: Cbx5
• Gene Accession No.: P45973
• Gene Alias: 2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
• Gene Symbols: Cbx5
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E. Coli.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23468
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1