Invitrogen™ HP1 alpha Polyclonal Antibody

Catalog No.	Quantity
PIPA517441	100 μL

Catalog No. PIPA517441 Supplier Invitrogen™ Supplier No. PA517441

Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with HP1 beta or HP1 gamma proteins.

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Specifications

• Antigen: HP1 alpha
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 120 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene: Cbx5
• Gene Accession No.: P45973, Q61686
• Gene Alias: 2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
• Gene Symbols: Cbx5
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to the carboxy terminus of human HP1alpha.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12419, 23468, 300266
• Target Species: Human, Mouse, Monkey, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG