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Invitrogen™ HP1 alpha Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA517441
Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with HP1 beta or HP1 gamma proteins.
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
Specifications
HP1 alpha | |
Polyclonal | |
Unconjugated | |
Cbx5 | |
2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha) | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12419, 23468, 300266 | |
-20°C | |
Liquid |
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
120 μg/mL | |
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
P45973, Q61686 | |
Cbx5 | |
Synthetic peptide corresponding to the carboxy terminus of human HP1alpha. | |
100 μL | |
Primary | |
Human, Mouse, Rat, Monkey | |
Antibody | |
IgG |
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