HP1 alpha Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™

Rabbit Polyclonal Antibody

Manufacturer:  Active Motif 39295

Catalog No. 50-199-3997

Description

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Specifications

• Antigen: HP1 alpha
• Applications: Western Blot
• Conjugate: Unconjugated
• Gene: Cbx5
• Format: Liquid
• Host Species: Rabbit
• Isotype: IgG
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human, Mouse

• Gene Symbol: Cbx5
• Concentration: Conc. Not Determined
• Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
• Gene Accession No.: P45973, Q61686
• Gene Alias: 2610029O15Rik; Antigen p25; BOS_4984; C75991; CBX5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
• Immunogen: This HP1 alpha antibody was raised against a recombinant protein corresponding to full-length recombinant mouse HP1 alpha.
• Quantity: 200 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 12419, 23468