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HP1 alpha Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
$147.50 - $565.00
Specifications
| Antigen | HP1 alpha |
|---|---|
| Concentration | Conc. Not Determined |
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-3998
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Active Motif
39296 |
10 μL |
Each for $147.50
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50-199-3997
|
Active Motif
39295 |
200 μL |
Each for $565.00
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Description
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.Specifications
| HP1 alpha | |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse | |
| P45973, Q61686 | |
| 12419, 23468 | |
| This HP1 alpha antibody was raised against a recombinant protein corresponding to full-length recombinant mouse HP1 alpha. | |
| Primary | |
| Antibody |
| Conc. Not Determined | |
| Polyclonal | |
| Liquid | |
| RUO | |
| whole serum with 30% glycerol and 0.035% sodium azide; pH | |
| 2610029O15Rik; Antigen p25; BOS_4984; C75991; CBX5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha) | |
| Cbx5 | |
| IgG | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Cbx5 |
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