HPV Type 16 E7 Mouse anti-Virus, Clone: 8C9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen 280006
In Western blot against the HPV16-E7 bacterially derived fusion protein, the antibody detects a 52 kD band which is composed of the HPV16-E7 protein (15 kDa) and the trpE protein (37 kDa). Positive reactivity for the 15 kDa HPV16-E7 expressed protein wasThe HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.
|HPV Type 16 E7, HPV 16-E7|
|PBS with 1% BSA and 0.1% sodium azide|
|HPV16E7; HPV 16-E7|
|Bacterially derived fusion protein containing the human papillomavirus tp 16 early protein E7 open reading frame.|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
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