Invitrogen™ HSF2 Polyclonal Antibody

Catalog No.	Quantity
PIPA586402	100 μL

Catalog No. PIPA586402 Supplier Invitrogen™ Supplier No. PA586402

Description

Rabbit Polyclonal Antibody

Purity is > 95% by SDS-PAGE.

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.

Specifications

• Antigen: HSF2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: HSF2
• Gene Accession No.: P38533, Q03933
• Gene Alias: AI661205; heat shock factor 2; heat shock factor protein 2; Heat shock transcription factor 2; HSF 2; Hsf2; HSTF 2; HSTF2; MGC117376; MGC156196; MGC75048
• Gene Symbols: HSF2
• Host Species: Rabbit
• Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human HSF2.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15500, 3298, 64441
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG