HSPA1L Monoclonal Antibody (OTI2H3), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-4411	100 μL

Catalog No. 50-168-4411 Supplier OriGene Supplier No. TA812115

Description

Mouse Monoclonal Antibody

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the "small heat shock proteins" is comprised of a diverse group of proteins from ∽15 to >30kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated strwess protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, turmor promoter (e.g. phorbol esters) and calcium ionophores. The expression of a 24kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

Specifications

• Antigen: HSPA1L
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2H3
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: HSPA1L
• Gene Accession No.: P34931
• Gene Alias: HSP70-1L, HSP70-HOM, HSP70T, hum70t
• Gene Symbols: HSPA1L
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 400-641 of human HSPA1L produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3305
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1