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Invitrogen™ HSPA4 Polyclonal Antibody
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Catalog No. PIPA529484
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100 μL
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PIPA529484 100 μL
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Catalog No. PIPA529484 Supplier Invitrogen™ Supplier No. PA529484
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, U87-MG, SK-N-SH, IMR32, SK-N-AS. Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (87%), Dog (98%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The HSP 70 family is composed of four highly conserved proteins: HSP 70, HSC 70, GRP 75 and GRP 78. HSP 70 expression is strongly induced in response to heat stress. HSP 70 and HSC 70 play key roles in the cytosolic endoplasmic reticulum and mitochondrial import machinery and are found in both the cytosol and nucleus of mammalian cells. GRP 78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. It has been postulated that members of the HSP 70 family act as force-generating motors, relying on the hydrolysis of ATP for their activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSPA4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene HSPA4
Gene Accession No. O88600, P34932
Gene Alias 70kDa; AI317151; APG2; APG-2; epididymis secretory sperm binding protein Li 5a; heat shock 70 kDa protein 4; heat shock 70kD protein 4; heat shock 70kDa protein 4; Heat shock 70-related protein APG-2; Heat shock protein; heat shock protein 4; heat shock protein Apg-2; heat shock protein family A (Hsp70) member 4; heat shock protein, 110 kDa; HEL-S-5a; HS24/P52; Hsp110; hsp70; hsp70 RY; Hsp70RY; Hspa4; HSPH2; Irp94; ischemia responsive 94 kDa protein; mKIAA4025; RY
Gene Symbols HSPA4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human HSPA4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 266759, 3308
Target Species Human, Monkey, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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