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ATCC hTERT ipn02.3 2?; Schwann cell; Human (Homo sapiens)
Supplier: ATCC CRL3392
hTERT ipn02.3 2λ is a Schwann cell that was isolated in 2008 from the sural nerve of a normal female. Through exogenous expression of human telomerase reverse transcriptase (hTERT) and murine cyclin-dependent kinase (mCdk4) using retroviral (and subsequently lentiviral) vectors carrying the hTERT and mCdk4 genes, normal (NF1 wild-type, +/+), neurofibroma-derived Schwann cells that were heterozygous (+/-) for NF1 mutation, and homozygous (-/-) for NF1 mutation, were immortalized. It is used for the research of Schwann cell biology, diseases, tumors, drug development, and neuroscience.
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