Abnova™ Human ABAT Full-length ORF (AAH08990, 1 a.a. - 116 a.a.) Recombinant Protein with GST-tag at N-terminal

Catalog No.	Quantity
89-954-451	2 μg

Catalog No. 89-954-451 Supplier Abnova™ Supplier No. H00000018P01

Description

Used for AP, Array, ELISA, WB-Re

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]

Sequence: MENHHSPKGQRRFQRKGVIGAVFCRMSQSSPSRQGKEGCCREGTAYAKAYQFMASHLSLGKPVSTGSIPRFNKALFNKQAKCKPNHYSFIGLSMLSPENFSIGCKYSVWFSETKGF

Specifications

• Accession Number: AAH08990
• For Use With (Application): Antibody Production, Protein Array, ELISA, Western Blot
• Formulation: 50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer.
• Gene ID (Entrez): 18
• Molecular Weight (g/mol): 38.5kDa
• Name: ABAT (Human) Recombinant Protein (P01)
• Purification Method: Glutathione Sepharose 4 Fast Flow
• Quality Control Testing: 12.5% SDS-PAGE Stained with Coomassie Blue.
• Quantity: 2 μg
• Storage Requirements: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Regulatory Status: RUO
• Gene Alias: FLJ17813/GABA-AT/GABAT/NPD009
• Common Name: ABAT
• Gene Symbol: ABAT
• Species: Wheat Germ (in vitro)
• Recombinant: Recombinant
• Protein Tag: GST
• Expression System: wheat germ expression system
• Form: Liquid