Invitrogen™ Human ACE2 (aa1-615) Fc Chimera Recombinant Protein

Description

Recombinant Protein

RP-87677 has been tested in indirect ELISA.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Specifications

• Accession Number: Q9BYF1
• Concentration: 1 mg/mL
• For Use With (Application): Control, ELISA, Western Blot
• Formulation: PBS with no preservative
• Gene ID (Entrez): 59272
• Molecular Weight (g/mol): 110 kDa
• Name: Human ACE2 (aa1-615) Fc Chimera
• Quantity: 200 μg
• Source: HEK293 cells
• Regulatory Status: RUO
• Gene Alias: 2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885
• Common Name: ACE2
• Gene Symbol: ACE2
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: Human ACE2 recombinant protein contains amino acids 1 -615 with a human Fc tag
• Content And Storage: -20°Cor to +80°C if preferred
• Expression System: HEK293 cells
• Form: Liquid
• Purity or Quality Grade: >95% by SDS-PAGE under reducing conditions