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Abnova™ Human ACVR2B (NP_001097.2, 161 a.a. - 512 a.a.) Partial Recombinant Protein with GST-tag expressed in baculovirus infected Sf21 cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P5490

Catalog No. 89-932-506


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Description

Description

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Specifications

Specifications

Baculovirus infected insect cell (Sf21) expression system
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
67kDa
Baculovirus infected insect cell (Sf21) expression system
94% by SDS-PAGE/CBB staining
5 ug
RUO
ACVR2B
The activity was determined by ELISA. The enzyme was incubated with biotinylated substrate protein, and after stopping kinase reaction by EDTA, the reaction solution was transferred into streptavidin- coated plate. Phosphorylation was detected by anti-phospho antibody and HRP-labeled anti-rabbit IgG. Substrate: ALK4 inactive mutant. ATP: 100 uM.
Yes
NP_001097.2
Liquid
93
ACVR2B (Human) Recombinant Protein
Glutathione sepharose chromatography
Loading 1 ug protein in SDS-PAGE
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
ACTRIIB/ActR-IIB/MGC116908
ACVR2B
Insect
GST
SDS
Documents
Product Certifications
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