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R&D Systems™ Human BMP-5 (NP_066551) VersaClone cDNA

Catalog No. RDC2551
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10 μg
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RDC2551 10 μg
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Description

This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.

  • BMP5 bone morphogenetic protein 5 [ Homo sapiens (human) ]
  • The BMP-5 insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided.
  • BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation.
  • There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs.
  • Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure.
  • Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers.
  • In addition, heterodimers, but not homodimers, are ventral mesoderm inducers.
  • Heterodimer activity may be mediated by a different or additional receptor subtype.
  • Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome.
  • Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.
  • For reasearch use only. Not for use in humans.

Specifications

Gene hBMP5
Accession Number NP_066551
Concentration 10 μg at 0.2 μg/μL
Formulation cDNA is provided in 10 mM Tris-Cl, pH 8.5
Insert Type 1378 bp
Gene ID (Entrez) 653
Content And Storage Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species Human
Quantity 10 μg
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